HCA Data Portal
Heart Network

Heart Network

The HCA datasets below focus on the network's tissues and are potential source datasets for integrated atlases.

Project TitleSpeciesMethodAnatomical EntityDisease (Donor)Cell Count Est.
A Cellular Atlas of Pitx2-Dependent Cardiac Development.

Mus musculus

10X 3' v2 sequencing

heart

normal

75,000

A human cell atlas of fetal gene expression.

Homo sapiens

sci-RNA-seq3

14 anatomical entities
normal

4,062,965

A human cell atlas of the pressure-induced hypertrophic heart

Homo sapiens

10x 3' v3

heart

aortic valve stenosis

88,536

A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates

Homo sapiens

5 library construction methods
2 anatomical entities
normal

78,901

A single-cell atlas of chromatin accessibility in the human genome

Homo sapiens

sci-RNA-seq

18 anatomical entities
normal

500,000

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.

Homo sapiens

4 library construction methods
8 anatomical entities
5 diseases

106,792

Cardiac cell type-specific gene regulatory programs and disease risk association

Homo sapiens

2 library construction methods

heart

normal

115,451

Cells of the adult human heart

Homo sapiens

2 library construction methods

heart

normal
3 diseases

791,000

Construction of A Human Cell Landscape by Single-cell mRNA-seq

Homo sapiens

Microwell-Seq

37 anatomical entities
normal
19 diseases

702,968

Defining cardiac functional recovery in end-stage heart failure at single-cell resolution.

Homo sapiens

10x 5' v1

heart

normal
5 diseases

185,881

Integrated multiomic characterization of congenital heart disease

Homo sapiens

3 library construction methods
2 anatomical entities
normal
22 diseases

157,273

Recruited macrophages elicit atrial fibrillation

Homo sapiens

10x 3' v3

heart

4 diseases

41,609

Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level

Homo sapiens

10x 3' transcription profiling

2 anatomical entities
normal
2 diseases

200,615

Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor.

Homo sapiens

3 library construction methods

heart

normal

54,140

Single Nucleus RNA-sequencing Reveals Altered Intercellular Communication and Dendritic Cell Activation in Nonobstructive Hypertrophic Cardiomyopathy

Homo sapiens

10x 3' v2

heart

normal
14 diseases

83,368

Single cell and lineage tracing studies reveal the impact of CD34+ cells on myocardial fibrosis during heart failure
2 species

10x 3' v3

heart

normal
2 diseases

82,042

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury.

Mus musculus

Smart-seq2

3 anatomical entities

Unspecified

272

Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation

Homo sapiens

2 library construction methods

heart

normal

76,073

Single-cell genomics improves the discovery of risk variants and genes of cardiac traits

Homo sapiens

2 library construction methods

heart

Unspecified

81,695

Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs

Homo sapiens

2 library construction methods
15 anatomical entities
normal

84,363

Single-cell transcriptomics provides insights into hypertrophic cardiomyopathy

Homo sapiens

CEL-seq2

heart

hypertrophic cardiomyopathy

2,292

Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure

Homo sapiens

10x 5' v1

heart

normal
2 diseases

270,475

Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure.

Homo sapiens

10x 3' v3

heart

normal

myocardial ischemia

99,684

Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function.

Homo sapiens

10x 3' v2

7 anatomical entities
normal

209,126

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy

Homo sapiens

10x 3' v3

heart

normal
2 diseases

600,000

Spatial multi-omic map of human myocardial infarction

Homo sapiens

3 library construction methods

heart

normal

myocardial infarction

12,184

Spatially resolved multiomics of human cardiac niches

Homo sapiens

3 library construction methods

heart

normal

asthma

355,822

Stress-induced RNA–chromatin interactions promote endothelial dysfunction

Homo sapiens

2 library construction methods

arterial blood vessel

5 diseases

Unspecified

Tabula Muris: Transcriptomic characterization of 20 organs and tissues from Mus musculus at single cell resolution

Mus musculus

Smart-seq2

18 anatomical entities
normal

100,605

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure
2 species
3 library construction methods
2 anatomical entities
normal
11 diseases

143,804

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Homo sapiens

3 library construction methods
24 anatomical entities
normal
10 diseases

481,120

Transcriptional and Cellular Diversity of the Human Heart

Homo sapiens

10x 3' v2

heart

normal

287,269

Transcriptomic Profiling of the Developing Cardiac Conduction System at Single-Cell Resolution.

Mus musculus

10x 3' v2

heart

normal

22,000