HCA Data Portal
Liver Network

Liver Network

The HCA datasets below focus on the network's tissues and are potential source datasets for integrated atlases.

Project TitleSpeciesMethodAnatomical EntityDisease (Donor)Cell Count Est.
A Human Liver Cell Atlas reveals Heterogeneity and Epithelial Progenitors

Homo sapiens

CEL-seq2

liver

3 diseases

10,000

A human cell atlas of fetal gene expression.

Homo sapiens

sci-RNA-seq3

14 anatomical entities
normal

4,062,965

A single cell atlas of the human liver tumor microenvironment

Homo sapiens

MARS-seq

liver

2 diseases

7,947

A single-cell atlas of chromatin accessibility in the human genome

Homo sapiens

sci-RNA-seq

18 anatomical entities
normal

500,000

An organoid and multi-organ developmental cell atlas reveals multilineage fate specification in the human intestine

Homo sapiens

2 library construction methods
5 anatomical entities

Unspecified

Unspecified

Blood and immune development in human fetal bone marrow and Down syndrome

Homo sapiens

9 library construction methods
4 anatomical entities
normal

trisomy 21

164,709

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.

Homo sapiens

4 library construction methods
8 anatomical entities
5 diseases

106,792

Construction of A Human Cell Landscape by Single-cell mRNA-seq

Homo sapiens

Microwell-Seq

37 anatomical entities
normal
19 diseases

702,968

Construction of a single-cell transcriptomic atlas of 58,243 liver cells from 4 donors and 4 recipient liver transplasnt patients to investigate early allograft dysfunction (EAD).

Homo sapiens

10x 3' v3

liver

normal

post-transplant lymphoproliferative disease

58,243

Cross-tissue immune cell analysis reveals tissue-specific features in humans

Homo sapiens

6 library construction methods
10 anatomical entities
normal

357,211

Decoding Human Megakaryocyte Development

Homo sapiens

2 library construction methods
3 anatomical entities
normal

18,698

Decoding human fetal liver haematopoiesis

Homo sapiens

2 library construction methods
4 anatomical entities
normal

223,112

Dissecting the clonal nature of allelic expression in somatic cells by single-cell RNA-seq
2 species

Smart-seq2

5 anatomical entities
normal

1,318

Dissecting the treatment-naive ecosystem of human melanoma brain metastasis.

Homo sapiens

6 library construction methods
5 anatomical entities

metastatic melanoma

114,455

Mapping the developing human immune system across organs
2 species
5 library construction methods
10 anatomical entities
normal

922,332

Modeling Hepatoblastoma: Identification of Distinct Tumor Cell Populations and Key Genetic Mechanisms through Single Cell Sequencing (scRNA-seq)

Homo sapiens

10x 3' v3

liver

blastoma

26,886

Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomics
2 species

10X 3' v2 sequencing

2 anatomical entities
normal
5 diseases

100,000

Single Cell, Single Nucleus and Spatial RNA Sequencing of the Human Liver Identifies Hepatic Stellate Cell and Cholangiocyte Heterogeneity

Homo sapiens

3 library construction methods

liver

Unspecified

Unspecified

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

Homo sapiens

10x 3' v2

liver

normal

30,000

Single cell analysis of human fetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors

Homo sapiens

Smart-seq2

liver

normal

1,475

Single cell landscape of mesenchymal and endothelial cells in healthy human liver

Homo sapiens

10x 3' v3

liver

3 diseases

106,941

Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis

Mus musculus

2 library construction methods

liver

normal

fibrotic liver disease

30,000

Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human.

Homo sapiens

10X 3' v2 sequencing

3 anatomical entities

Unspecified

207,000

Single-cell RNA-Seq of human hepatocyte-derived liver progenitor-like cells

Homo sapiens

10x 3' v2

liver

liver hemangioma

7,461

Single-cell atlas of diverse immune populations in the advanced biliary tract cancer microenvironment

Homo sapiens

2 library construction methods
5 anatomical entities
3 diseases

45,851

Single-cell deciphering of human fetal innate lymphoid cell development

Homo sapiens

10x 3' v3

6 anatomical entities
normal

Unspecified

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.

Homo sapiens

10x 3' v2

2 anatomical entities
normal

liver cancer

24,250

Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs

Homo sapiens

2 library construction methods
15 anatomical entities
normal

84,363

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
2 species
4 library construction methods

liver

normal
34 diseases

918,268

Tabula Muris: Transcriptomic characterization of 20 organs and tissues from Mus musculus at single cell resolution

Mus musculus

Smart-seq2

18 anatomical entities
normal

100,605

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Homo sapiens

3 library construction methods
24 anatomical entities
normal
10 diseases

481,120