HCA Data Portal
Reproduction Network

Reproduction Network

The HCA datasets below focus on the network's tissues and are potential source datasets for integrated atlases.

Project TitleSpeciesMethodAnatomical EntityDisease (Donor)Cell Count Est.
A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra

Homo sapiens

10X v2 sequencing

prostate gland

normal

108,700

A human cell atlas of fetal gene expression.

Homo sapiens

sci-RNA-seq3

14 anatomical entities
normal

4,062,965

A multi-omic single-cell landscape of human gynecologic malignancies

Homo sapiens

2 library construction methods
2 anatomical entities
4 diseases

150,000

A single cell atlas of the human proximal epididymis reveals cell-type specific functions and distinct roles for CFTR

Homo sapiens

10X 3' v2 sequencing

testis

testicular cancer

7,500

A single-cell and single-nucleus RNA-seq toolbox for fresh and frozen human tumors.
2 species
2 library construction methods
6 anatomical entities
6 diseases

216,490

A single-cell atlas of chromatin accessibility in the human genome

Homo sapiens

sci-RNA-seq

18 anatomical entities
normal

500,000

A single-cell survey of the human first-trimester placenta and decidua

Homo sapiens

2 library construction methods

placenta

normal

22,526

Cellular atlas of the human ovary using morphologically guided spatial transcriptomics and single-cell sequencing

Homo sapiens

10x 3' v3

ovary

Unspecified

Unspecified

Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified by scRNA-seq

Homo sapiens

10x 3' v3

fallopian tube

hydrosalpinx

99,218

Comparison of manual and two types of bioprinted kidney organoids by single cell RNA-seq.

Homo sapiens

10x 3' v3

skin of prepuce of penis

normal

106,040

Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues

Homo sapiens

Nx1-seq

uterus

endometrioid adenocarcinoma

Unspecified

Construction of A Human Cell Landscape by Single-cell mRNA-seq

Homo sapiens

Microwell-Seq

37 anatomical entities
normal
19 diseases

702,968

Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation [Female]

Homo sapiens

10x 3' V2 sequencing

ovary

normal

25,000

Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation [Male]

Homo sapiens

10x 3' V2 sequencing

testis

normal

30,000

Genomic profiling of human spermatogonial stem cells

Homo sapiens

Fluidigm C1-based library preparation

testis

normal

175

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

Homo sapiens

2 library construction methods

uterus

normal

55,000

Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids.

Homo sapiens

Drop-seq

uterus

normal

Unspecified

Profiling of transcribed cis-regulatory elements in single cells.

Homo sapiens

6 library construction methods
3 anatomical entities
normal

60,443

Reconstructing the human first trimester fetal-maternal interface using single cell transcriptomics

Homo sapiens

2 library construction methods
3 anatomical entities
normal

orofaciodigital syndrome VIII

70,000

Single cell RNA-seq of HeLa CCL2

Homo sapiens

Smart-like

uterus

adenocarcinoma

720

Single cell analysis of endometriosis reveals a coordinated transcriptional program driving immunotolerance and angiogenesis across eutopic and ectopic tissues

Homo sapiens

2 library construction methods
3 anatomical entities
normal

endometriosis

122,000

Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal- Niche Interactions

Homo sapiens

Smart-like

gonad

normal

43

Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell

Homo sapiens

3 library construction methods
3 anatomical entities
normal
3 diseases

21,964

Single-cell RNA-seq to decipher the subpopulations of human decidual leukocytes in normal and RSA pregnancies

Homo sapiens

10x 3' v2

uterus

normal

habitual spontaneous abortion

30,000

Single-cell RNA-sequencing reveals the landscape of cervical cancer heterogeneity

Homo sapiens

10x 3' V2 sequencing

uterus

cervical cancer

Unspecified

Single-cell Transcriptome Atlas of Testis Aging

Homo sapiens

10x 3' v3

testis

normal
2 diseases

23,088

Single-cell Transcriptome Atlas of the Human Corpus Cavernosum

Homo sapiens

10x 3' v3

penis

normal
2 diseases

37,892

Single-cell reconstruction of follicular remodeling in the human adult ovary

Homo sapiens

10x 3' V2 sequencing

ovary

cancer

Unspecified

Single-cell sequencing reveals novel cellular heterogeneity in uterine leiomyomas.

Homo sapiens

10x 5' v2

uterus

leiomyoma

Unspecified

Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse

Homo sapiens

2 library construction methods

vagina

normal
3 diseases

81,026

Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle

Homo sapiens

2 library construction methods

endometrium

normal

71,000

Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function.

Homo sapiens

10x 3' v2

7 anatomical entities
normal

209,126

Spatial multiomics map of trophoblast development in early pregnancy

Homo sapiens

5 library construction methods
2 anatomical entities
normal

trisomy 18

325,665

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Homo sapiens

3 library construction methods
24 anatomical entities
normal
10 diseases

481,120

The myogenesis program drives clonal selection and drug resistance in rhabdomyosarcoma

Homo sapiens

5 library construction methods
12 anatomical entities
2 diseases

764,251

The regulatory landscapes of human ovarian ageing

Homo sapiens

2 library construction methods

ovary

normal

84,118

The single cell atlas of human endometrial stromal cells

Homo sapiens

10x 3' v3

uterus

normal

7,768

Transcriptome Landscape of Human Folliculogenesis Reveals Oocytes and Granulosa Cells Interactions

Homo sapiens

Smart-like

ovary

normal

148