HCA Data Portal
Skin Network

Skin Network

The HCA datasets below focus on the network's tissues and are potential source datasets for integrated atlases.

Project TitleSpeciesMethodAnatomical EntityDisease (Donor)Cell Count Est.
A Single-Cell Transcriptomic Atlas of Human Skin Aging.

Homo sapiens

10x 3' v2

skin of body

normal

35,678

A single-cell atlas of chromatin accessibility in the human genome

Homo sapiens

sci-RNA-seq

18 anatomical entities
normal

500,000

An Optimized Tissue Dissociation Protocol for Single-Cell RNA Sequencing Analysis of Fresh and Cultured Human Skin Biopsies

Homo sapiens

10x 3' v3

skin of body

normal
2 diseases

24,029

Anatomically distinct fibroblast subsets determine skin autoimmune patterns.

Homo sapiens

10x 3' v2

skin of body

normal

Progressive vitiligo

50,000

Classification of human chronic inflammatory skin disease based on single-cell immune profiling

Homo sapiens

3 library construction methods

skin of body

normal
5 diseases

158,037

Comparison of manual and two types of bioprinted kidney organoids by single cell RNA-seq.

Homo sapiens

10x 3' v3

skin of prepuce of penis

normal

106,040

Construction of A Human Cell Landscape by Single-cell mRNA-seq

Homo sapiens

Microwell-Seq

37 anatomical entities
normal
19 diseases

702,968

Decoding human fetal liver haematopoiesis

Homo sapiens

2 library construction methods
4 anatomical entities
normal

223,112

Defining Transcriptional Signatures of Human Hair Follicle Cell States

Homo sapiens

2 library construction methods

skin of body

normal

1,422

Developmental cell programs are co-opted in inflammatory skin disease.

Homo sapiens

10x 3' v2

skin of body

normal
2 diseases

7,000

Differential cell composition and split epidermal differentiation in human palm, sole, and hip skin

Homo sapiens

2 library construction methods

skin of body

Unspecified

18,524

Dissecting the clonal nature of allelic expression in somatic cells by single-cell RNA-seq
2 species

Smart-seq2

5 anatomical entities
normal

1,318

Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution

Homo sapiens

Fluidigm C1-based library preparation

2 anatomical entities
normal

1,001

Fate-mapping within human iPSC-derived kidney organoids reveals conserved mammalian nephron progenitor lineage relationships.

Homo sapiens

10x 3' v2

skin of body

normal

5,365

Genome-Wide DNA Hypermethylation in the Wound-Edge of Chronic Wound Patients Opposes Closure by Impairing Epithelial to Mesenchymal Transition

Homo sapiens

2 library construction methods
3 anatomical entities
normal

type 2 diabetes mellitus

36,487

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development.

Homo sapiens

Fluidigm C1-based library preparation

3 anatomical entities
normal

734

Human melanocyte development and melanoma dedifferentiation at single-cell resolution

Homo sapiens

Smart-seq2

skin of body

normal

9,719

Identification of neural oscillations and epileptiform changes in human brain organoids.

Homo sapiens

10x 3' v3

zone of skin

Rett syndrome

54,942

In Vitro and In Vivo Development of the Human Airway at Single-Cell Resolution

Homo sapiens

10x 3' v2

3 anatomical entities

Unspecified

Unspecified

Lineage recording in human cerebral organoids.

Homo sapiens

3 library construction methods

skin of body

normal

103,520

Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex.

Homo sapiens

Fluidigm C1-based library preparation

2 anatomical entities
normal

301

Mapping the developing human immune system across organs
2 species
5 library construction methods
10 anatomical entities
normal

922,332

Melanoma infiltration of stromal and immune cells

Mus musculus

Smart-seq2

3 anatomical entities

melanoma (disease)

6,639

Multi-scale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma

Homo sapiens

2 library construction methods
12 anatomical entities
normal

basal cell carcinoma

233,379

Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin

Homo sapiens

2 library construction methods

skin of body

normal

diffuse cutaneous systemic sclerosis

65,199

Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.

Homo sapiens

10x 3' v2

skin of body

normal
3 diseases

Unspecified

Organoid single-cell genomic atlas uncovers human-specific features of brain development

Homo sapiens

5 library construction methods
3 anatomical entities
normal

19,916

Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation.

Homo sapiens

10x 3' v2

skin of body

normal

1,000,000

Profiling of transcribed cis-regulatory elements in single cells.

Homo sapiens

6 library construction methods
3 anatomical entities
normal

60,443

Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.

Homo sapiens

Smart-seq2

2 anatomical entities
normal

455

Retinal ganglion cell-specific genetic regulation in primary open angle glaucoma

Homo sapiens

10x 3' v2

skin of body

normal

primary open angle glaucoma

247,520

Robust temporal map of human in vitro myelopoiesis using single-cell genomics.

Homo sapiens

3 library construction methods

skin of body

normal

470,000

Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis

Homo sapiens

Fluidigm C1-based library preparation

3 anatomical entities
normal

systemic lupus erythematosus

899

Single cell RNA-Seq of E18.5 developing mouse kidney and human kidney organoids
2 species

10x 3' v2

2 anatomical entities
normal

14,585

Single cell RNAseq of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium

Homo sapiens

10x 3' v2

skin epidermis

polydactyly

11,541

Single cell analysis of endometriosis reveals a coordinated transcriptional program driving immunotolerance and angiogenesis across eutopic and ectopic tissues

Homo sapiens

2 library construction methods
3 anatomical entities
normal

endometriosis

122,000

Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis conducted by skin resident cells

Homo sapiens

10x 3' v3

skin of body

normal

psoriasis

24,259

Single cell transcriptomics of human epidermis identifies basal stem cell transition states.

Homo sapiens

10x 3' v2

skin of body

normal

17,553

Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer

Homo sapiens

10x TCR enrichment

2 anatomical entities

gastric adenocarcinoma

200,000

Single-Cell Lymphocyte Heterogeneity in Advanced Cutaneous T-cell Lymphoma Skin Tumors

Homo sapiens

10X 3' v2

skin of body

normal

primary cutaneous T-cell lymphoma

14,056

Single-Cell RNA Sequencing Reveals Human iPS Cell-derived Alveolar Type 1 Cells in Alveolar Organoids

Homo sapiens

Smart-seq

dermis

normal

83

Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma

Homo sapiens

10x 5' v1

2 anatomical entities
normal
2 diseases

47,172

Single-cell analysis reveals congruence between kidney organoids and human fetal kidney

Homo sapiens

10x 3' V2 sequencing

skin of body

normal

8,323

Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis

Homo sapiens

2 library construction methods

skin of body

normal

Atopic dermatitis

17,307

Single-cell atlas of diverse immune populations in the advanced biliary tract cancer microenvironment

Homo sapiens

2 library construction methods
5 anatomical entities
3 diseases

45,851

Single-cell deciphering of human fetal innate lymphoid cell development

Homo sapiens

10x 3' v3

6 anatomical entities
normal

Unspecified

Single-cell transcriptome analysis reveals the dynamics of human immune cells during early fetal skin development

Homo sapiens

2 library construction methods

skin of body

normal

57,358

Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs

Homo sapiens

2 library construction methods
15 anatomical entities
normal

84,363

Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming

Homo sapiens

10x 3' v2

skin of body

normal

15,457

Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma.

Homo sapiens

4 library construction methods
8 anatomical entities
normal

neuroblastoma

220,527

Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type-specific immune regulation in atopic dermatitis.

Homo sapiens

2 library construction methods

skin of body

normal
3 diseases

37,548

Single-cell transcriptomics reveals distinct effector profiles of infiltrating T cells in lupus skin and kidney

Homo sapiens

10x 3' v3

skin of body

normal
2 diseases

3,499

Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function.

Homo sapiens

10x 3' v2

7 anatomical entities
normal

209,126

Skin single cell universe identifies IL-1B/IL23A co-producing CD14+ type 3 dendritic cells in psoriasis

Homo sapiens

Smart-seq2

skin of body

2 diseases

1,567

Spatial and single-cell transcriptional profiling identifies functionally distinct human dermal fibroblast subpopulations

Homo sapiens

Smart-seq2

abdomen

normal

184

Tabula Muris: Transcriptomic characterization of 20 organs and tissues from Mus musculus at single cell resolution

Mus musculus

Smart-seq2

18 anatomical entities
normal

100,605

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure
2 species
3 library construction methods
2 anatomical entities
normal
11 diseases

143,804

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Homo sapiens

3 library construction methods
24 anatomical entities
normal
10 diseases

481,120

The emergent landscape of the mouse gut endoderm at single-cell resolution

Mus musculus

10x 3' v2

3 anatomical entities
normal

112,201

The immune cell atlas of human neuroblastoma

Homo sapiens

10x 3' v2

7 anatomical entities

neuroblastoma

46,261

The myogenesis program drives clonal selection and drug resistance in rhabdomyosarcoma

Homo sapiens

5 library construction methods
12 anatomical entities
2 diseases

764,251

Village in a dish: a model system for population-scale hiPSC studies

Homo sapiens

10x 3' v3

skin of body

glaucoma

88,927

scRNA-seq experiments on human foreskin fibroblasts, foreskin fibroblasts induced directly to retina pigment epithelium, and induced pluripotent stem cell derived retina pigment epithelium.

Homo sapiens

10x 5' v1

skin of body

normal

8,372

αβγδ T cells play a vital role in fetal human skin development and immunity

Homo sapiens

10x 3' v2

skin of body

normal

5,490